肺癌是癌症相关死亡率的主要原因。尽管新技术（例如图像分割）对于改善检测和较早诊断至关重要，但治疗该疾病仍然存在重大挑战。特别是，尽管治愈性分辨率增加，但许多术后患者仍会出现复发性病变。因此，非常需要预后工具，可以更准确地预测患者复发的风险。在本文中，我们探讨了卷积神经网络（CNN）在术前计算机断层扫描（CT）图像中存在的分割和复发风险预测。首先，随着医学图像分割的最新进展扩展，剩余的U-NET用于本地化和表征每个结节。然后，确定的肿瘤将传递给第二个CNN进行复发风险预测。该系统的最终结果是通过随机的森林分类器产生的，该分类器合成具有临床属性的第二个网络的预测。分割阶段使用LIDC-IDRI数据集，并获得70.3％的骰子得分。复发风险阶段使用了国家癌症研究所的NLST数据集，并获得了73.0％的AUC。我们提出的框架表明，首先，自动结节分割方法可以概括地为各种多任务系统提供管道，其次，深度学习和图像处理具有改善当前预后工具的潜力。据我们所知，这是第一个完全自动化的细分和复发风险预测系统。

Three main points: 1. Data Science (DS) will be increasingly important to heliophysics; 2. Methods of heliophysics science discovery will continually evolve, requiring the use of learning technologies [e.g., machine learning (ML)] that are applied rigorously and that are capable of supporting discovery; and 3. To grow with the pace of data, technology, and workforce changes, heliophysics requires a new approach to the representation of knowledge.

Image classification with small datasets has been an active research area in the recent past. However, as research in this scope is still in its infancy, two key ingredients are missing for ensuring reliable and truthful progress: a systematic and extensive overview of the state of the art, and a common benchmark to allow for objective comparisons between published methods. This article addresses both issues. First, we systematically organize and connect past studies to consolidate a community that is currently fragmented and scattered. Second, we propose a common benchmark that allows for an objective comparison of approaches. It consists of five datasets spanning various domains (e.g., natural images, medical imagery, satellite data) and data types (RGB, grayscale, multispectral). We use this benchmark to re-evaluate the standard cross-entropy baseline and ten existing methods published between 2017 and 2021 at renowned venues. Surprisingly, we find that thorough hyper-parameter tuning on held-out validation data results in a highly competitive baseline and highlights a stunted growth of performance over the years. Indeed, only a single specialized method dating back to 2019 clearly wins our benchmark and outperforms the baseline classifier.

Dataset scaling, also known as normalization, is an essential preprocessing step in a machine learning pipeline. It is aimed at adjusting attributes scales in a way that they all vary within the same range. This transformation is known to improve the performance of classification models, but there are several scaling techniques to choose from, and this choice is not generally done carefully. In this paper, we execute a broad experiment comparing the impact of 5 scaling techniques on the performances of 20 classification algorithms among monolithic and ensemble models, applying them to 82 publicly available datasets with varying imbalance ratios. Results show that the choice of scaling technique matters for classification performance, and the performance difference between the best and the worst scaling technique is relevant and statistically significant in most cases. They also indicate that choosing an inadequate technique can be more detrimental to classification performance than not scaling the data at all. We also show how the performance variation of an ensemble model, considering different scaling techniques, tends to be dictated by that of its base model. Finally, we discuss the relationship between a model's sensitivity to the choice of scaling technique and its performance and provide insights into its applicability on different model deployment scenarios. Full results and source code for the experiments in this paper are available in a GitHub repository.\footnote{https://github.com/amorimlb/scaling\_matters}

The devastation caused by the coronavirus pandemic makes it imperative to design automated techniques for a fast and accurate detection. We propose a novel non-invasive tool, using deep learning and imaging, for delineating COVID-19 infection in lungs. The Ensembling Attention-based Multi-scaled Convolution network (EAMC), employing Leave-One-Patient-Out (LOPO) training, exhibits high sensitivity and precision in outlining infected regions along with assessment of severity. The Attention module combines contextual with local information, at multiple scales, for accurate segmentation. Ensemble learning integrates heterogeneity of decision through different base classifiers. The superiority of EAMC, even with severe class imbalance, is established through comparison with existing state-of-the-art learning models over four publicly-available COVID-19 datasets. The results are suggestive of the relevance of deep learning in providing assistive intelligence to medical practitioners, when they are overburdened with patients as in pandemics. Its clinical significance lies in its unprecedented scope in providing low-cost decision-making for patients lacking specialized healthcare at remote locations.

Objective: Imbalances of the electrolyte concentration levels in the body can lead to catastrophic consequences, but accurate and accessible measurements could improve patient outcomes. While blood tests provide accurate measurements, they are invasive and the laboratory analysis can be slow or inaccessible. In contrast, an electrocardiogram (ECG) is a widely adopted tool which is quick and simple to acquire. However, the problem of estimating continuous electrolyte concentrations directly from ECGs is not well-studied. We therefore investigate if regression methods can be used for accurate ECG-based prediction of electrolyte concentrations. Methods: We explore the use of deep neural networks (DNNs) for this task. We analyze the regression performance across four electrolytes, utilizing a novel dataset containing over 290000 ECGs. For improved understanding, we also study the full spectrum from continuous predictions to binary classification of extreme concentration levels. To enhance clinical usefulness, we finally extend to a probabilistic regression approach and evaluate different uncertainty estimates. Results: We find that the performance varies significantly between different electrolytes, which is clinically justified in the interplay of electrolytes and their manifestation in the ECG. We also compare the regression accuracy with that of traditional machine learning models, demonstrating superior performance of DNNs. Conclusion: Discretization can lead to good classification performance, but does not help solve the original problem of predicting continuous concentration levels. While probabilistic regression demonstrates potential practical usefulness, the uncertainty estimates are not particularly well-calibrated. Significance: Our study is a first step towards accurate and reliable ECG-based prediction of electrolyte concentration levels.

Candidate axiom scoring is the task of assessing the acceptability of a candidate axiom against the evidence provided by known facts or data. The ability to score candidate axioms reliably is required for automated schema or ontology induction, but it can also be valuable for ontology and/or knowledge graph validation. Accurate axiom scoring heuristics are often computationally expensive, which is an issue if you wish to use them in iterative search techniques like level-wise generate-and-test or evolutionary algorithms, which require scoring a large number of candidate axioms. We address the problem of developing a predictive model as a substitute for reasoning that predicts the possibility score of candidate class axioms and is quick enough to be employed in such situations. We use a semantic similarity measure taken from an ontology's subsumption structure for this purpose. We show that the approach provided in this work can accurately learn the possibility scores of candidate OWL class axioms and that it can do so for a variety of OWL class axioms.

The rapid growth of machine translation (MT) systems has necessitated comprehensive studies to meta-evaluate evaluation metrics being used, which enables a better selection of metrics that best reflect MT quality. Unfortunately, most of the research focuses on high-resource languages, mainly English, the observations for which may not always apply to other languages. Indian languages, having over a billion speakers, are linguistically different from English, and to date, there has not been a systematic study of evaluating MT systems from English into Indian languages. In this paper, we fill this gap by creating an MQM dataset consisting of 7000 fine-grained annotations, spanning 5 Indian languages and 7 MT systems, and use it to establish correlations between annotator scores and scores obtained using existing automatic metrics. Our results show that pre-trained metrics, such as COMET, have the highest correlations with annotator scores. Additionally, we find that the metrics do not adequately capture fluency-based errors in Indian languages, and there is a need to develop metrics focused on Indian languages. We hope that our dataset and analysis will help promote further research in this area.

The intersection of ground reaction forces in a small, point-like area above the center of mass has been observed in computer simulation models and human walking experiments. This intersection point is often called a virtual pivot point (VPP). With the VPP observed so ubiquitously, it is commonly assumed to provide postural stability for bipedal walking. In this study, we challenge this assumption by questioning if walking without a VPP is possible. Deriving gaits with a neuromuscular reflex model through multi-stage optimization, we found stable walking patterns that show no signs of the VPP-typical intersection of ground reaction forces. We, therefore, conclude that a VPP is not necessary for upright, stable walking. The non-VPP gaits found are stable and successfully rejected step-down perturbations, which indicates that a VPP is not primarily responsible for locomotion robustness or postural stability. However, a collision-based analysis indicates that non-VPP gaits increased the potential for collisions between the vectors of the center of mass velocity and ground reaction forces during walking, suggesting an increased mechanical cost of transport. Although our computer simulation results have yet to be confirmed through experimental studies, they already strongly challenge the existing explanation of the VPP's function and provide an alternative explanation.

Many business workflows require extracting important fields from form-like documents (e.g. bank statements, bills of lading, purchase orders, etc.). Recent techniques for automating this task work well only when trained with large datasets. In this work we propose a novel data augmentation technique to improve performance when training data is scarce, e.g. 10-250 documents. Our technique, which we call FieldSwap, works by swapping out the key phrases of a source field with the key phrases of a target field to generate new synthetic examples of the target field for use in training. We demonstrate that this approach can yield 1-7 F1 point improvements in extraction performance.